| Career Leaders Wins | ||
| Player | Total | |
| 1 | Cy Young | 511 |
| 2 | Walter Johnson | 417 |
| 3 | Pete Alexander | 373 |
| Christy Mathewson | 373 | |
| 4 | Pud Galvin | 364 |
| 5 | Warren Spahn | 363 |
| 6 | Kid Nichols | 361 |
| 7 | Greg Maddux | 355 |
| 8 | Roger Clemens | 354 |
| 9 | Tim Keefe | 342 |
| 10 | Steve Carlton | 329 |
| 11 | John Clarkson | 328 |
| 12 | Eddie Plank | 326 |
| 13 | Nolan Ryan | 324 |
| Don Sutton | 324 | |
| 14 | Phil Niekro | 318 |
| 15 | Gaylord Perry | 314 |
| 16 | Tom Seaver | 311 |
| 17 | Charley Radbourn | 309 |
| 18 | Mickey Welch | 307 |
| 19 | Tom Glavine | 305 |
| 20 | Randy Johnson | 303 |
| 21 | Lefty Grove | 300 |
| Early Wynn | 300 | |
| 22 | Bobby Mathews | 297 |
| 29 | Tommy John | 288 |
| 28 | Bert Blyleven | 287 |
| 25 | Robin Roberts | 286 |
| 26 | Tony Mullane | 284 |
| Fergie Jenkins | 284 | |
| 27 | Jim Kaat | 283 |
| 28 | Red Ruffing | 273 |
| 29 | Mike Mussina | 270 |
| Burleigh Grimes | 270 | |
| 30 | Jim Palmer | 268 |
| 31 | Eppa Rixey | 266 |
| Bob Feller | 266 | |
| 32 | Jim McCormick | 265 |
| 33 | Gus Weyhing | 264 |
| 34 | Ted Lyons | 260 |
| 35 | Jamie Moyer | 258 |
| 36 | Jack Morris | 254 |
| Red Faber | 254 | |
| 37 | Carl Hubbell | 253 |
| Al Spalding | 253 | |
| 38 | Bob Gibson | 251 |
| 39 | Vic Willis | 249 |
| 40 | Jack Quinn | 247 |
| 41 | Joe McGinnity | 246 |
| 42 | Dennis Martinez | 245 |
| Jack Powell | 245 | |
| Amos Rusie | 245 | |
| 43 | Juan Marichal | 243 |
| 44 | Herb Pennock | 240 |
| Frank Tanana | 240 | |
| 45 | David Wells | 239 |
| Mordecai Brown | 239 | |
| 46 | Clark Griffith | 237 |
| Waite Hoyt | 237 | |
| 47 | Whitey Ford | 236 |
| 48 | Tommy Bond | 234 |
| 49 | Charlie Buffinton | 233 |
| 50 | Sam Jones | 229 |
| Will White | 229 | |
| Luis Tiant | 229 | |
| Andy Pettitte | 229 | |
| 51 | George Mullin | 228 |
| 52 | Catfish Hunter | 224 |
| Jim Bunning | 224 | |
| 53 | Paul Derringer | 223 |
| Mel Harder | 223 | |
| 54 | Jerry Koosman | 222 |
| Hooks Dauss | 222 | |
| 55 | Joe Niekro | 221 |
| Jerry Reuss | 220 | |
| 56 | Kenny Rogers | 219 |
| Pedro Martinez | 219 | |
| 57 | Earl Whitehill | 218 |
| Bob Caruthers | 218 | |
| 58 | Mickey Lolich | 217 |
| Freddie Fitzsimmons | 217 | |
| 59 | Charlie Hough | 216 |
| Wilbur Cooper | 216 | |
| Curt Schilling | 216 | |
| Jim Perry | 215 | |
| 60 | Stan Coveleski | 215 |
| 61 | Rick Reuschel | 214 |
| 62 | John Smoltz | 213 |
| 63 | Chief Bender | 212 |
| 64 | Kevin Brown | 211 |
| Bob Welch | 211 | |
| Billy Pierce | 211 | |
| Bobo Newsom | 211 | |
| 65 | Jesse Haines | 210 |
| 66 | Vida Blue | 209 |
| Don Drysdale | 209 | |
| Milt Pappas | 209 | |
| 67 | Eddie Cicotte | 208 |
| 68 | Bob Lemon | 207 |
| Hal Newhouser | 207 | |
| Carl Mays | 207 | |
| 69 | Al Orth | 204 |
| Orel Hershiser | 204 | |
| 70 | Silver King | 203 |
| Lew Burdette | 203 | |
| Jack Stivetts | 203 | |
| 71 | Rube Marquard | 201 |
| Charley Root | 201 | |
| 72 | George Uhle | 200 |
| Chuck Finley | 200 | |